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Year : 2017  |  Volume : 2  |  Issue : 1  |  Page : 7-11

Impact of incretin-related agents on endothelial cell function

1 Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
2 Manda Memorial Hospital, Sapporo, Japan
3 Kurihara Clinic, Sapporo, Japan
4 Aoki Clinic, Sapporo, Japan
5 The membership of the SAIS Study Group is provided in the Acknowledgements

Correspondence Address:
Hideaki Miyoshi
Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo
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Source of Support: This work was supported by The Japan Diabetes Foundation Inc. and The Waksman Foundation of Japan Inc. , Conflict of Interest: None

DOI: 10.4103/2542-3975.202726

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Incretin-related drugs, such as dipeptidyl peptidase-4 (DPP-4) inhibitors and glucagon-like peptide-1 (GLP-1) analogues, have been clinically available and widely used to treat patients with type 2 diabetes mellitus. Accumulating evidence indicates that these agents exert glycemic control and have various other favorable effects, including prevention of atherosclerosis. It is important to assess and manage early-phase atherosclerosis, but whether diabetic therapeutics including incretin-related drugs improve or maintain vascular endothelial cell function has not been fully determined. We previously published prospective clinical trials focused on flow-mediated dilation in patients with type 2 diabetes, who did not have severe atherosclerosis, using two different incretin-related drugs: a DPP-4 inhibitor and a GLP-1 analogue. These trials showed that these therapeutic agents did not improve endothelial cell function. In this article, we discuss how incretin-related drugs contribute, if at all, to vascular endothelial cell function, atherosclerosis, and beta-cell function, based on our clinical trials and previous evidence.

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